HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 66618519, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 42053071 | HCID 42053071 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 66618519 | HCID 66618519 | 92% |
Reaction Steps
To a cooled solution of (S)-3-(4-fluoro-phenylcarbamoyl)-piperidine-1-carboxylic acid tert-butyl ester (0.34 g, 1.05 mmol) in dichloromethane (5 mL) was added dropwise 5.2 mL of HCl 4N (dioxane solution) and the solution was stirred at R.T. for 45 min. The solvent was evaporated under reduced pressure to give the title compound as a white solid (0.252 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08030331B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-fb011ea11f634b81902b6502d23183fd |
| Source note | uspto-grants-2011_10 |