Hydrochloric Acid → HCID 66618519, compound

HRID 1661191Notes

Reaction equation

HRID 1661191 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH2:11][C@H:10]([C:14](=[O:23])[NH:15][C:16]2[CH:21]=[CH:20][C:19]([F:22])=[CH:18][CH:17]=2)[CH2:9]1)=O)(C)(C)C.[ClH:24]>ClCCl>[ClH:24].[F:22][C:19]1[CH:18]=[CH:17][C:16]([NH:15][C:14]([C@H:10]2[CH2:11][CH2:12][CH2:13][NH:8][CH2:9]2)=[O:23])=[CH:21][CH:20]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 42053071HCID 42053071, compound

Product 1

HCID 66618519HCID 66618519, compoundYield 92%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a cooled solution of (S)-3-(4-fluoro-phenylcarbamoyl)-piperidine-1-carboxylic acid tert-butyl ester (0.34 g, 1.05 mmol) in dichloromethane (5 mL) was added dropwise 5.2 mL of HCl 4N (dioxane solution) and the solution was stirred at R.T. for 45 min. The solvent was evaporated under reduced pressure to give the title compound as a white solid (0.252 g).

Workup

  1. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-fb011ea11f634b81902b6502d23183fd
Source dataset
uspto-grants-2011_10
Patent number
US08030331B2

Reaction notes

Loading…