1-Bromo-4-fluorobenzene → [1-(6'-Fluoro-2'-methoxy-biphenyl-3-yl)-1h-imidazol-4-yl]-(4-fluoro-phenyl)-methanone
Reaction equation
CON(C)[C:4]([C:6]1[N:7]=[CH:8][N:9]([C:11]2[CH:12]=[C:13]([C:17]3[C:22]([F:23])=[CH:21][CH:20]=[CH:19][C:18]=3[O:24][CH3:25])[CH:14]=[CH:15][CH:16]=2)[CH:10]=1)=[O:5].Br[C:28]1[CH:33]=[CH:32][C:31]([F:34])=[CH:30][CH:29]=1>>[F:23][C:22]1[C:17]([C:13]2[CH:14]=[CH:15][CH:16]=[C:11]([N:9]3[CH:10]=[C:6]([C:4]([C:28]4[CH:33]=[CH:32][C:31]([F:34])=[CH:30][CH:29]=4)=[O:5])[N:7]=[CH:8]3)[CH:12]=2)=[C:18]([O:24][CH3:25])[CH:19]=[CH:20][CH:21]=1Participants
3
Procedure
This compound is prepared by method C using compound 12g and 1-bromo-4-fluorobenzene
Workup
- customThis compound is prepared by method C
Sources & evidence
- ORD record
- ord-97f5a22a00e6437e9dff6a526976ef1a
- Source dataset
- uspto-grants-2011_10
- Patent number
- US08030339B2
Reaction notes
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