(1S)-2-amino-1-phenylethan-1-ol → HCID 67429313, compound

HRID 1661471Notes

Reaction equation

HRID 1661471 reaction equation
C1([C@H](O)CN)C=CC=CC=1.FC1C=CC(N2C3C(=CC(I)=CC=3)C=N2)=CC=1.[F:28][C:29]1[CH:34]=[CH:33][C:32]([N:35]2[C:43]3[C:38](=[CH:39][C:40]([O:44][C@H:45]([C:49]4[CH:54]=[CH:53][CH:52]=[CH:51][CH:50]=4)[C@@H:46]([NH2:48])C)=[CH:41][CH:42]=3)[CH:37]=[N:36]2)=[CH:31][CH:30]=1>>[F:28][C:29]1[CH:30]=[CH:31][C:32]([N:35]2[C:43]3[C:38](=[CH:39][C:40]([O:44][C@@H:45]([C:49]4[CH:50]=[CH:51][CH:52]=[CH:53][CH:54]=4)[CH2:46][NH2:48])=[CH:41][CH:42]=3)[CH:37]=[N:36]2)=[CH:33][CH:34]=1

Participants

4

Reactant 3

HCID 643217(1S)-2-amino-1-phenylethan-1-olHCID 592511281-(4-fluorophenyl)-5-iodo-1H-indazoleHCID 59339817(alphaS,betaR)-beta-{[1-(4-Fluorophenyl)-1H-indazole-5-yl]oxy}-alpha-methylbenzeneethanamine

Product 1

HCID 67429313HCID 67429313, compound

Procedure

Prepared from (1S)-1-phenyl-1-hydroxy-ethan-2-amine (294 mg, 2.15 mmol) and 1-(4-fluorophenyl)-5-iodoindazole (484 mg, 1.43 mmol) according to the protocol for 1a. Yield: 175 mg (23%).

Sources & evidence

ORD record
ord-ddc6fd400db54e59a2fc3305cd97174c
Source dataset
uspto-grants-2011_10
Patent number
US08030340B2

Reaction notes

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