HCID 67428955, compound → HCID 54751409, compound

HRID 1661497Notes

Reaction equation

HRID 1661497 reaction equation
BrC1SC2C(O)=C(C(=O)CCC=O)C(=O)N(C)C=2C=1.[O:20]1CCC[O:22][CH:21]1[CH2:26][CH2:27][C:28]([C:30]1[C:35](=[O:36])[N:34]([CH3:37])[C:33]2[CH:38]=[C:39]([Br:41])[S:40][C:32]=2[C:31]=1[OH:42])=[O:29]>C(O)(=O)C>[Br:41][C:39]1[S:40][C:32]2[C:31]([OH:42])=[C:30]([C:28](=[O:29])[CH2:27][CH2:26][C:21]([OH:22])=[O:20])[C:35](=[O:36])[N:34]([CH3:37])[C:33]=2[CH:38]=1

Participants

4

Reactant 2

HCID 67428955HCID 67428955, compoundHCID 86631546HCID 86631546, compound

Product 1

HCID 54751409HCID 54751409, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
100 °C

Procedure

4-(2-Bromo-7-hydroxy-4-methyl-5-oxo-4,5-dihydrothieno[3,2-b]pyridin-6-yl)-4-oxobutanal. To 6-(3-(1,3-dioxan-2-yl)propanoyl)-2-bromo-7-hydroxy-4-methylthieno[3,2-b]pyridin-5(4H)-one (155 mg, 385 μmol) was added 80% aqueous acetic acid (7.7 mL), and the resulting mixture was stirred for 2 hours at 100° C. The reaction product precipitated on addition of water, and was filtered and then dried in a vacuum oven to give the title compound.

Workup

  1. customThe reaction product precipitated on addition of water
  2. filtrationwas filtered
  3. customdried in a vacuum oven

Sources & evidence

ORD record
ord-b05698b5793a41dfab68f3b0e4a94ed1
Source dataset
uspto-grants-2011_10
Patent number
US08030346B2

Reaction notes

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