Potassium Carbonate → Methanesulfonic acid 5-bromo-pyridin-3-yl ester

A flask is charged with 5-bromo-pyridin-3-ol (0.200 g, 1.126 mmol), potassium carbonate (0.212 g, 1.487 mmol) and acetone (3 mL). Methanesulfonyl chloride (0.143 g, 1.239 mmol) is then added dropwise. After 2 h, an other portion of methanesulfonyl chloride (0.071 g, 0.61 mmol) is added. After overnight stirring, the suspension is concentrated, diluted with ethyl acetate and filtered through a pad of silica gel. The filtrate is concentrated in vacuo to give a residue, which is purified by silica gel flash chromatography (heptane-ethyl acetate, 4:1 to 7:3) to give a mixture of product and starting material. The fractions are combined, washed three times with saturated aqueous sodium bicarbonate and dried over MgSO4. Concentration in vacuo gives methanesulfonic acid 5-bromo-pyridin-3-yl ester as an oil. 1H NMR (400 MHz, CDCl3) δ ppm 3.25 (s, 3H), 7.86 (m, 1H), 8.52 (d, J=2.3 Hz, 1H), 8.67 (d, J=1.8 Hz, 1H).

1. concentrationthe suspension is concentrated
2. additiondiluted with ethyl acetate
3. filtrationfiltered through a pad of silica gel
4. concentrationThe filtrate is concentrated in vacuo
5. customto give a residue, which
6. customis purified by silica gel flash chromatography (heptane-ethyl acetate, 4:1 to 7:3)
7. customto give
8. additiona mixture of product
9. washwashed three times with saturated aqueous sodium bicarbonate
10. dry with materialdried over MgSO4
11. concentrationConcentration in vacuo

ORD record

ord-e72aad92aab842f7b627b94f5666595f

Source dataset

uspto-grants-2011_10

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08030334B2