(1-Methyl-1H-indol-2-yl)boronic acid → 2-[5-(1-methyl-1H-indol-2-yl)-pyridin-3-ylmethyl]-isoindole-1,3-dione

HRID 1661697Notes

Reaction equation

HRID 1661697 reaction equation
Br[C:2]1[CH:3]=[C:4]([CH2:8][N:9]2[C:17](=[O:18])[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[C:10]2=[O:19])[CH:5]=[N:6][CH:7]=1.[CH3:20][N:21]1[C:29]2[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=2)[CH:23]=[C:22]1B(O)O>>[CH3:20][N:21]1[C:29]2[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=2)[CH:23]=[C:22]1[C:2]1[CH:3]=[C:4]([CH2:8][N:9]2[C:17](=[O:18])[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[C:10]2=[O:19])[CH:5]=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 22733820(1-Methyl-1H-indol-2-yl)boronic acidHCID 229922612-((5-Bromopyridin-3-yl)methyl)isoindoline-1,3-dione

Product 1

HCID 582155602-[5-(1-methyl-1H-indol-2-yl)-pyridin-3-ylmethyl]-isoindole-1,3-dione

Procedure

2-(5-Bromo-pyridin-3-ylmethyl)-isoindole-1,3-dione (Example 186b) and 1-methyl-indole-2-boronic acid are processed according to the method described in Example 100 to give 2-[5-(1-methyl-1H-indol-2-yl)-pyridin-3-ylmethyl]-isoindole-1,3-dione as a solid. MS (ESI) m/z 368.09 (M+H)+.

Sources & evidence

ORD record
ord-7487b10c4cd149e8804e827545253a1f
Source dataset
uspto-grants-2011_10
Patent number
US08030334B2

Reaction notes

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