反应详情

A mixture of 15 grams (0.1 moles) of 2-carboxybenzaldehyde and 17.82 grams of 2,4,4-trimethylpentyl phosphinic acid in 100 mL of xylene is heated to reflux and 1.8 mL of water is collected by azeotropic distillation using a Dean-Stark receiver. The xylene solvent is removed in vacuo and the residue is crystallized with a mixture of 50 mL of ethyl acetate and 100 mL heptane to yield 17.2 grams (56% yield) (3-oxo-1,3-dihydro-isobenzofuran-1-yl)-(2,4,4-trimethylpentyl)-phosphinic acid as an off-white powder, mp 117-121° C.

1. temperatureis heated
2. temperatureto reflux
3. distillation1.8 mL of water is collected by azeotropic distillation
4. customThe xylene solvent is removed in vacuo
5. customthe residue is crystallized with a mixture of 50 mL of ethyl acetate and 100 mL heptane