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HRID1661872

反应详情

EQUATION

反应方程式

HRID 1661872 的结构方程式

REACTANTS

反应物

1
结构：CCOC(=O)C(CC(=O)OC1CC(C)CCC1C(C)C)(NC(=O)OC(C)(C)C)C(N)=O
HCID66704183

未命名化合物

PRODUCTS

生成物

1
结构：CCOC(=O)[C@](CC(=O)OC1CC(C)CCC1C(C)C)(NC(=O)OC(C)(C)C)C(N)=O
HCID66704283

未命名化合物

收率 11.9%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC(C)=O
溶剂HCID180

Acetone

C3H6O

PROCEDURE

实验过程

Ethyl 2-(tert-butoxycarbonylamino)-2-carbamoyl-3-[(−)-menthyloxycarbonyl]propionate (737 mg, 1.67 mmol) was dissolved in acetone (3.69 g) and the solution was placed at 5-10° C. The precipitated crystals were filtered to give ethyl (2R)-2-(tert-butoxycarbonylamino)-2-carbamoyl-3-[(−)-menthyloxycarbonyl]propionate (88 mg) as a white crystal. mp. 176° C., optical purity: 82.6% d.e.

WORKUP

后处理

  1. customwas placed at 5-10° C
  2. filtrationThe precipitated crystals were filtered