HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 2-(tert-butoxycarbonylamino)-2-carbamoyl-3-[(-)-menthyloxycarbonyl]propionate → ethyl (2R)-2-(tert-butoxycarbonylamino)-2-carbamoyl-3-[(-)-menthyloxycarbonyl]propionate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 2-(tert-butoxycarbonylamino)-2-carbamoyl-3-[(-)-menthyloxycarbonyl]propionate | HCID 66704183 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | ethyl (2R)-2-(tert-butoxycarbonylamino)-2-carbamoyl-3-[(-)-menthyloxycarbonyl]propionate | HCID 66704283 | 11.9% |
Reaction Steps
Ethyl 2-(tert-butoxycarbonylamino)-2-carbamoyl-3-[(−)-menthyloxycarbonyl]propionate (737 mg, 1.67 mmol) was dissolved in acetone (3.69 g) and the solution was placed at 5-10° C. The precipitated crystals were filtered to give ethyl (2R)-2-(tert-butoxycarbonylamino)-2-carbamoyl-3-[(−)-menthyloxycarbonyl]propionate (88 mg) as a white crystal. mp. 176° C., optical purity: 82.6% d.e.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08030486B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-140c3ca31c884a33939470acfd768a03 |
| Source note | uspto-grants-2011_10 |