2-Bromoethyl methyl ether → 4-Iodo-7-methoxy-1-(2-methoxyethyl)-2-[4-(1-methylethyl)phenyl]-1H-benzimidazole

HRID 1661889Notes

Reaction equation

HRID 1661889 reaction equation
[I:1][C:2]1[C:10]2[N:9]=[C:8]([C:11]3[CH:16]=[CH:15][C:14]([CH:17]([CH3:19])[CH3:18])=[CH:13][CH:12]=3)[NH:7][C:6]=2[C:5]([O:20][CH3:21])=[CH:4][CH:3]=1.Br[CH2:23][CH2:24][O:25][CH3:26]>>[I:1][C:2]1[C:10]2[N:9]=[C:8]([C:11]3[CH:16]=[CH:15][C:14]([CH:17]([CH3:19])[CH3:18])=[CH:13][CH:12]=3)[N:7]([CH2:23][CH2:24][O:25][CH3:26])[C:6]=2[C:5]([O:20][CH3:21])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 809722-Bromoethyl methyl etherHCID 67431836HCID 67431836, compound

Product 1

HCID 114423054-Iodo-7-methoxy-1-(2-methoxyethyl)-2-[4-(1-methylethyl)phenyl]-1H-benzimidazole

Procedure

The title compound is prepared starting from 4-iodo-2-(4-isopropyl-phenyl)-7-methoxy-1H-benzoimidazole and (2-bromoethyl)-methyl ether using the same reaction conditions as described in Example 1. The title compound is obtained as a colorless oil.

Workup

  1. customThe title compound is prepared
  2. customthe same reaction conditions

Sources & evidence

ORD record
ord-0501052f29b149419b39acf59f7cde3b
Source dataset
uspto-grants-2011_10
Patent number
US08030497B2

Reaction notes

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