反应详情

A solution of 748 mg (1.77 mmol) N-[5-bromo-3-methoxy-2-(2-methoxy-ethylamino)-phenyl]-4-isopropyl-benzamide in 10 ml AcOH is stirred at 100° C. for 2 h. The reaction mixture is cooled to room temperature 200 ml ethyl acetate is added. The solution is washed with 4N NaOH (2×) and with water and brine, dried over MgSO4, filtered and concentrated in vacuo. The residue is purified by flash-chromatography on silica gel (hexane:EtOAc=3:1) to afford 625 mg of the title compound as a colorless solid.

1. additionis added
2. washThe solution is washed with 4N NaOH (2×) and with water and brine
3. dry with materialdried over MgSO4
4. filtrationfiltered
5. concentrationconcentrated in vacuo
6. customThe residue is purified by flash-chromatography on silica gel (hexane:EtOAc=3:1)