HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1661943Generated: October 31, 2026
Methanesulfonyl chloride → methanesulfonic acid 4-bromo-2-(4-isopropyl-phenyl)-7-methoxy-1-(2-methoxy-ethyl)-1H-benzoimidazol-5-ylmethyl ester
https://huagongshe.com/reaction/1661943
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | [4-bromo-2-(4-isopropyl-phenyl)-7-methoxy-1-(2-methoxy-ethyl)-1H-benzoimidazol-5-yl]-methanol | HCID 57771990 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | methanesulfonic acid 4-bromo-2-(4-isopropyl-phenyl)-7-methoxy-1-(2-methoxy-ethyl)-1H-benzoimidazol-5-ylmethyl ester | HCID 57771995 | 101.6% |
Reaction Steps
A solution of 200 mg (0.462 mmol) [4-Bromo-2-(4-isopropyl-phenyl)-7-methoxy-1-(2-methoxy-ethyl)-1H-benzoimidazol-5-yl]-methanol is dissolved in 5 ml CH2Cl2. The solution is cooled to 0° C. and methanesulfonyl chloride (47 ul, 0.600 mmol) and Huenig's base (103 ul, 0.600 mmol) is added. After 1 h the reaction is extracted with CH2Cl2/10% citric acid. The organic layer is dried over MgSO4, filtered and concentrated in vacuo to give 240 mg of material which is used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08030497B2 |
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| Source dataset | uspto-grants-2011_10 |
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| ORD ID | ord-d10f36f1d4944a81b1927a369874fac8 |
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| Source note | uspto-grants-2011_10 |
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