反应详情

温度

0 °C

A solution of 200 mg (0.462 mmol) [4-Bromo-2-(4-isopropyl-phenyl)-7-methoxy-1-(2-methoxy-ethyl)-1H-benzoimidazol-5-yl]-methanol is dissolved in 5 ml CH2Cl2. The solution is cooled to 0° C. and methanesulfonyl chloride (47 ul, 0.600 mmol) and Huenig's base (103 ul, 0.600 mmol) is added. After 1 h the reaction is extracted with CH2Cl2/10% citric acid. The organic layer is dried over MgSO4, filtered and concentrated in vacuo to give 240 mg of material which is used without further purification.

1. extractionAfter 1 h the reaction is extracted with CH2Cl2/10% citric acid
2. dry with materialThe organic layer is dried over MgSO4
3. filtrationfiltered
4. concentrationconcentrated in vacuo