Hydrogen chloride-ethyl acetate → HCID 67429376, compound

HRID 1662062Notes

Reaction equation

HRID 1662062 reaction equation
C(OC([N:8]([CH2:18][CH2:19][O:20][CH3:21])[C:9]1[CH:10]=[C:11]([CH:15]=[CH:16][CH:17]=1)[C:12]([OH:14])=[O:13])=O)(C)(C)C.[ClH:22].C(OCC)(=O)C>C(OCC)(=O)C>[ClH:22].[CH3:21][O:20][CH2:19][CH2:18][NH:8][C:9]1[CH:10]=[C:11]([CH:15]=[CH:16][CH:17]=1)[C:12]([OH:14])=[O:13]

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 59453869HCID 59453869, compound

Product 1

HCID 67429376HCID 67429376, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a mixture of 3-[(tert-butoxycarbonyl)(2-methoxyethyl)amino]benzoic acid (0.57 g) and ethyl acetate (10 ml) was added a 4 M hydrogen chloride/ethyl acetate solution (5.0 ml) under ice-cooling, followed by stirring at room temperature over one night. The solid precipitated was collected by filtration to obtain 3-[(2-methoxyethyl)amino]benzoic acid hydrochloride (0.38 g).

Workup

  1. temperaturecooling
  2. customThe solid precipitated
  3. filtrationwas collected by filtration

Sources & evidence

ORD record
ord-d17b375638be4bf5a99b18f4d7526483
Source dataset
uspto-grants-2011_10
Patent number
US08030489B2

Reaction notes

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