Perchloric Acid → 1-Boc-3-aminopyrrolidine

HRID 1662082Notes

Reaction equation

HRID 1662082 reaction equation
Cl(O)(=O)(=O)=O.[C:6]([O:10][C:11]([N:13]1[CH2:17][CH2:16][C@H:15]([NH2:18])[CH2:14]1)=[O:12])([CH3:9])([CH3:8])[CH3:7].C(OC(N1CC[C@@H](N)C1)=O)(C)(C)C>>[C:6]([O:10][C:11]([N:13]1[CH2:17][CH2:16][CH:15]([NH2:18])[CH2:14]1)=[O:12])([CH3:9])([CH3:7])[CH3:8]

Participants

4

Reactant 3

HCID 24247Perchloric AcidHCID 854070(R)-(+)-1-Boc-3-aminopyrrolidineHCID 854071tert-butyl (3S)-3-aminopyrrolidine-1-carboxylate

Product 1

HCID 27563701-Boc-3-aminopyrrolidine

Procedure

column: manufactured by Daicel Chemical Industries, Ltd., {CROWNPAK 150×4.6 mm}, mobile phase: aqueous perchloric acid solution (pH 1.5), flow rate: 1.0 ml/min, detection: UV 210 nm, column temperature: 35° C., retention time: (S)-1-(tert-butoxycarbonyl)-3-aminopyrrolidine; 24.1 min, (R)-1-(tert-butoxycarbonyl)-3-aminopyrrolidine; 27.0 min

Workup

  1. custom35° C., retention time
  2. custom27.0 min

Sources & evidence

ORD record
ord-f0c34cbfd1eb41c8a015092b4636d72c
Source dataset
uspto-grants-2011_10
Patent number
US08030501B2

Reaction notes

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