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4-Bromo-2-(trifluoromethyl)pyridine → 1-(5-Bromo-2-fluorophenyl)-4-fluoro-1-(2-(trifluoromethyl)pyridin-4-yl)-1H-isoindol-3-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Bromo-2-(trifluoromethyl)pyridine | HCID 23436950 | — |
| 反応物 | HCID 86641816 | HCID 86641816 | — |
| 生成物 | 1-(5-Bromo-2-fluorophenyl)-4-fluoro-1-(2-(trifluoromethyl)pyridin-4-yl)-1H-isoindol-3-amine | HCID 58579538 | 90% |
反応手順
The title compound was synthesized as described for example 11i in 90% yield starting from N-((5-bromo-2-fluorophenyl)(2-cyano-3-fluorophenyl)methylene)propane-2-sulfinamide (0.980 g, 2.38 mmol) and 4-bromo-2-(trifluoromethyl)pyridine (0.646 g, 2.86 mmol). Purification was achieved by flash chromatography using a gradient of 100% CH2Cl2 to 30% 0.1M NH3 in MeOH in CH2Cl2.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08030500B2 |
| 出典データセット | uspto-grants-2011_10 |
| ORD ID | ord-f858d39b5c884b4e81518b1d6bac0ef5 |
| 出典メモ | uspto-grants-2011_10 |