反应详情

A mixture of 6-bromo-2,4-dimethyl-3-hydroxypyridine (8.7 g, 43.1 mmol), iodomethane (4.0 mL, 64.6 mmol) and potassium carbonate (11.9 g, 86.1 mmol) in acetone (250 mL) was heated at reflux temperature for 3 hours. The reaction mixture was then cooled to room temperature and filtered through a pad of Celite®. The filtrate was concentrated under reduced pressure and the residue was purified by flash column chromatography using 20% ethyl acetate in hexane to afford 7.9 g (85%) of the title compound.

1. temperaturewas heated
2. temperatureat reflux temperature for 3 hours
3. filtrationfiltered through a pad of Celite®
4. concentrationThe filtrate was concentrated under reduced pressure
5. customthe residue was purified by flash column chromatography