HRID1662232

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID44119381

[5-(Methanesulfonyl)pyridin-3-yl]boronic acid

C6H8BNO4S

结构：NC1=NC(c2ccnc(C(F)(F)F)c2)(c2cc(Br)ccc2F)c2cccc(F)c21

HCID58579538

未命名化合物

PRODUCTS

生成物

结构：CS(=O)(=O)c1cncc(-c2ccc(F)c(C3(c4ccnc(C(F)(F)F)c4)N=C(N)c4c(F)cccc43)c2)c1

HCID46205965

未命名化合物

收率 58%

PROCEDURE

实验过程

The title compound was synthesized as described for Example 1 in 58% yield, starting from 1-(5-bromo-2-fluorophenyl)-4-fluoro-1-(2-(trifluoromethyl)pyridin-4-yl)-1H-isoindol-3-amine (64.8 mg, 0.14 mmol) and 5-(methylsulfonyl)pyridin-3-ylboronic acid (30.6 mg, 0.15 mmol).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-5f890121b8d74fbbb764f9183f67bb4b
来源数据集: uspto-grants-2011_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08030500B2
来源说明: uspto-grants-2011_10

反应 SMILES

Br[C:2]1[CH:3]=[CH:4][C:5]([F:29])=[C:6]([C:8]2([C:19]3[CH:24]=[CH:23][N:22]=[C:21]([C:25]([F:28])([F:27])[F:26])[CH:20]=3)[C:16]3[C:11](=[C:12]([F:17])[CH:13]=[CH:14][CH:15]=3)[C:10]([NH2:18])=[N:9]2)[CH:7]=1.[CH3:30][S:31]([C:34]1[CH:35]=[C:36](B(O)O)[CH:37]=[N:38][CH:39]=1)(=[O:33])=[O:32]>>[F:17][C:12]1[CH:13]=[CH:14][CH:15]=[C:16]2[C:11]=1[C:10]([NH2:18])=[N:9][C:8]2([C:6]1[CH:7]=[C:2]([C:36]2[CH:37]=[N:38][CH:39]=[C:34]([S:31]([CH3:30])(=[O:33])=[O:32])[CH:35]=2)[CH:3]=[CH:4][C:5]=1[F:29])[C:19]1[CH:24]=[CH:23][N:22]=[C:21]([C:25]([F:26])([F:27])[F:28])[CH:20]=1