5-(Methylsulphonyl)pyridine-3-boronic acid → 4-Fluoro-1-(2-fluoro-5-(5-(methylsulfonyl)pyridin-3-yl)phenyl)-1-(2-(trifluoromethyl)pyridin-4-yl)-1H-isoindol-3-amine

Participants

Role	Name	HCID	Charge
Reactant	5-(Methylsulphonyl)pyridine-3-boronic acid	HCID 44119381	—
Reactant	1-(5-Bromo-2-fluorophenyl)-4-fluoro-1-(2-(trifluoromethyl)pyridin-4-yl)-1H-isoindol-3-amine	HCID 58579538	—
Product	4-Fluoro-1-(2-fluoro-5-(5-(methylsulfonyl)pyridin-3-yl)phenyl)-1-(2-(trifluoromethyl)pyridin-4-yl)-1H-isoindol-3-amine	HCID 46205965	58%

Reaction Steps

The title compound was synthesized as described for Example 1 in 58% yield, starting from 1-(5-bromo-2-fluorophenyl)-4-fluoro-1-(2-(trifluoromethyl)pyridin-4-yl)-1H-isoindol-3-amine (64.8 mg, 0.14 mmol) and 5-(methylsulfonyl)pyridin-3-ylboronic acid (30.6 mg, 0.15 mmol).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08030500B2
Source dataset	uspto-grants-2011_10
ORD ID	ord-5f890121b8d74fbbb764f9183f67bb4b
Source note	uspto-grants-2011_10