HRID1662253
反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
AUXILIARIES
试剂、催化剂与溶剂
CONDITIONS
反应条件
- 温度
- 140 °C
PROCEDURE
实验过程
1-(3-Bromophenyl)-1-(2-(difluoromethyl)-6-methylpyridin-4-yl)-4-fluoro-1H-isoindol-3-amine (40 mg, 0.09 mmol), pyrimidin-5-ylboronic acid (12.22 mg, 0.10 mmol) and (1,1′-bis (diphenylphosphino)ferrocene)-dichloropalladium(II) (7.37 mg, 8.96 μmol) were mixed in THF (3 mL). Aqueous sodium carbonate (2M) (0.134 mL, 0.27 mmol) was added and the mixture was heated in a microwave reactor for 40 min at 140° C. The mixture was filtered through a pad of Celite®, eluated with DCM (15 mL) and concentrated in vacuo. Purification by preparative HPLC afforded 11.0 mg (27%) of the title compound.
WORKUP
后处理
- filtrationThe mixture was filtered through a pad of Celite®
- concentrationconcentrated in vacuo
- customPurification by preparative HPLC