Formic Acid → HCID 178420844, compound

HRID 1662287Notes

Reaction equation

HRID 1662287 reaction equation
[NH2:1][C:2]1[C:7]([NH2:8])=[C:6]([C:9]2[S:10][CH:11]=[CH:12][CH:13]=2)[CH:5]=[CH:4][N:3]=1.[NH4+].[OH-].[CH:16](O)=O>>[S:10]1[CH:11]=[CH:12][CH:13]=[C:9]1[C:6]1[CH:5]=[CH:4][N:3]=[C:2]2[NH:1][CH:16]=[N:8][C:7]=12

Participants

4

Reactant 3

HCID 284Formic AcidHCID 14923Ammonium HydroxideHCID 579367942,3-Diamino-4-(2-thienyl)pyridine

Product 1

HCID 178420844HCID 178420844, compoundYield 96%

Procedure

A solution of Compound 3 (956 mg, 5.0 mmol) in formic acid (15 ml) was refluxed for 12 hours. To the reaction mixture, 24 ml of 28% NH4OH was added on an ice-cold bath. The resulting precipitate was filtered, washed with H2O and ethyl ether, and then dried at 60° C. for 12 hours to give 7-(2-thienyl)-3H-imidazo[4,5-b]pyridine (970 mg, 96%).

Workup

  1. filtrationThe resulting precipitate was filtered
  2. washwashed with H2O and ethyl ether
  3. customdried at 60° C. for 12 hours

Sources & evidence

ORD record
ord-1e039c43876d4dcd8eac0833d5307265
Source dataset
uspto-grants-2011_10
Patent number
US08030478B2

Reaction notes

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