Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Adenosine | HCID 60961 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | HCID 178463183 | HCID 178463183 | — |
| Reactant | HCID 178511674 | HCID 178511674 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Product | HCID 178478407 | HCID 178478407 | — |
Reaction Steps
A stirred suspension of 2,6-dichloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purine (Intermediate 1 in WO03/080613) (1.14 kg) in n-butanol (1.7 L) was treated with trans-1,4-diaminocyclohexane (239.2 g) and di-iso-propylethylamine (2.5 L), then heated at 75° C. for 17 hours. The suspension was allowed to cool to ambient temperature, filtered, washed with n-butanol (2×2.3 L) and dried in vacuo at 60° C. to give the title compound (0.9 kg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07737126B2 |
|---|
| Source dataset | uspto-grants-2010_06 |
|---|
| ORD ID | ord-1907f8719254478fb587098d77c72465 |
|---|
| Source note | uspto-grants-2010_06 |
|---|
