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HRID16623

反应详情

EQUATION

反应方程式

HRID 16623 的结构方程式

REACTANTS

反应物

4
结构：Nc1ncnc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
HCID60961

Adenosine

C10H13N5O4

结构：CCN(C(C)C)C(C)C
HCID81531

Diisopropylethylamine

C8H19N

结构：CCn1nnc([C@@H]2O[C@@H](n3cnc4c(N[C@H]5CC[C@H](Nc6nc(Cl)nc7c6ncn7[C@@H]6O[C@@H](c7nnn(CC)n7)[C@H](CC(=O)[O-])[C@H]6CC(=O)[O-])CC5)nc(Cl)nc43)[C@H](CC(=O)[O-])[C@H]2CC(=O)[O-])n1
HCID178463183

未命名化合物

结构：N[C@H]1CC[C@H](N)CC1
HCID178511674

未命名化合物

PRODUCTS

生成物

1
结构：Clc1nc(N[C@H]2CC[C@H](Nc3nc(Cl)nc4c3ncn4C3CCCCO3)CC2)c2ncn(C3CCCCO3)c2n1
HCID178478407

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCCCO
溶剂HCID263

1-Butanol

C4H10O

CONDITIONS

反应条件

温度
75 °C

PROCEDURE

实验过程

A stirred suspension of 2,6-dichloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purine (Intermediate 1 in WO03/080613) (1.14 kg) in n-butanol (1.7 L) was treated with trans-1,4-diaminocyclohexane (239.2 g) and di-iso-propylethylamine (2.5 L), then heated at 75° C. for 17 hours. The suspension was allowed to cool to ambient temperature, filtered, washed with n-butanol (2×2.3 L) and dried in vacuo at 60° C. to give the title compound (0.9 kg).

WORKUP

后处理

  1. temperatureto cool to ambient temperature
  2. filtrationfiltered
  3. washwashed with n-butanol (2×2.3 L)
  4. customdried in vacuo at 60° C.