HuagongsheHuagongshe Chemistry Print Report · For research reference only
N,N-Dimethylformamide--water (1/1) → 3-(3-Hydroxyphenyl)-5-hexenoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N,N-Dimethylformamide--water (1/1) | HCID 21962138 | — |
| Reactant | 5-(1-(3-Hydroxyphenyl)-3-butenyl)-2,2-dimethyl-1,3-dioxane-4,6-dione | HCID 57705981 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 3-(3-Hydroxyphenyl)-5-hexenoic acid | HCID 57706582 | 97% |
Reaction Steps
A solution of 43.1 (3.4 g, 12 mmol) in 10:1 DMF/water (48 mL) was stirred overnight at 90° C. The mixture was cooled to room temperature, diluted with EtOAc, washed with 1 N HCl and brine, dried (MgSO4), and concentrated to afford 43.2 (2.4 g) as a pink oil. The crude product was used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08030354B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-d4cdf97db02c4a2cbb4e698ce8a40727 |
| Source note | uspto-grants-2011_10 |