反应详情

To a solution of 43.2 (2.4 g, 12 mmol) in MeOH (25 mL) was added five drops of sulfuric acid. The mixture was stirred overnight at reflux, cooled to room temperature, diluted with EtOAc, washed with water and brine, dried (MgSO4), and concentrated. The crude product was chromatographed on silica gel (0-25% EtOAc/hexane) to afford 43.3 (2.2 g, 84%) as a colorless oil.

1. temperatureat reflux
2. washwashed with water and brine
3. dry with materialdried (MgSO4)
4. concentrationconcentrated
5. customThe crude product was chromatographed on silica gel (0-25% EtOAc/hexane)