反应详情

In an ice-bath, methyl 3-formyl-4-hydroxybenzoate 66.38A (900 mg, 5 mmol) (commercially available from Aldrich) was dissolved in 5 mL THF. Then cyclopropylmagnesium bromide, 0.5 m in THF (22000 μL, 11 mmol) (commercially available from Aldrich) was added slowly. The reaction was raised to room temperature immediately and stirred at room temperature for 2 hours. After quenching with 1N HCl 11 mL, the reaction was extracted with EtOAc and dried. Silica gel chromatography afforded 950 mg of the product 66.38B (85%).

1. customAfter quenching with 1N HCl 11 mL
2. extractionthe reaction was extracted with EtOAc
3. customdried