(2-(1,1-Dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-4-yl)methanol → [2'-Fluoro-5'-methoxy-2-(1-methoxy-2,2-dimethyl-but-3-enyl)-biphenyl-4-yl]-methanol

HRID 1662424Notes

Reaction equation

HRID 1662424 reaction equation
C[O:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:16]=[C:15]([O:17][CH3:18])[CH:14]=[CH:13][C:12]=2[F:19])=[C:7]([CH:20]([O:26][CH3:27])[C:21]([CH3:25])([CH3:24])[CH:22]=[CH2:23])[CH:6]=1)=O.CC(C1C=C(CO)C=CC=1C1C=C(OC)C=CC=1F)(C)C>>[F:19][C:12]1[CH:13]=[CH:14][C:15]([O:17][CH3:18])=[CH:16][C:11]=1[C:8]1[CH:9]=[CH:10][C:5]([CH2:3][OH:2])=[CH:6][C:7]=1[CH:20]([O:26][CH3:27])[C:21]([CH3:24])([CH3:25])[CH:22]=[CH2:23]

Participants

3

Reactant 2

HCID 57705540(2-(1,1-Dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-4-yl)methanolHCID 577061812'-Fluoro-5'-methoxy-2-(1-methoxy-2,2-dimethyl-but-3-enyl)-biphenyl-4-carboxylic acid methyl ester

Product 1

HCID 57467633[2'-Fluoro-5'-methoxy-2-(1-methoxy-2,2-dimethyl-but-3-enyl)-biphenyl-4-yl]-methanol

Procedure

Compound 66.41F was synthesized from 66.41E by a method analogous to that used to prepare compound 8.9 from 8.8. MS ESI m/e: 345.2 (M+H)+.

Sources & evidence

ORD record
ord-9f7e0b4de6fd434a80fe91513a23c9aa
Source dataset
uspto-grants-2011_10
Patent number
US08030354B2

Reaction notes

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