反应详情

温度

50 °C

To a solution of methyl 4-(5-fluoro-2-methoxypyridin-4-yl)-3-(1-vinylcyclopentyl)benzoate 66.67E (51.0 mg, 143 μmol) in THF (2.0 mL) was slowly added LAH, (1.0M solution in diethyl ether) (0.30 mL, 287 μmol) at room temperature. The resulting mixture was stirred at 50° C. for 1 hour. Standard work up conditions were employed and the solvent was removed. The desired product was used in the next step without further purification. MS ESI (pos.) m/e: 328.2 (M+H)+.

1. customat room temperature
2. customthe solvent was removed
3. customThe desired product was used in the next step without further purification