HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1) → [2'-Fluoro-5'-methoxy-2-(1-methoxy-cyclopentyl)-biphenyl-4-yl]-methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1) | HCID 466102 | — |
| Reactant | tert-Butyl-[2'-fluoro-5'-methoxy-2-(1-methoxy-cyclopentyl)-biphenyl-4-ylmethoxy]-dimethyl-silane | HCID 57706027 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | [2'-Fluoro-5'-methoxy-2-(1-methoxy-cyclopentyl)-biphenyl-4-yl]-methanol | HCID 57706279 | 61% |
Reaction Steps
To a solution of 66.68E (66 mg, 168 μmol) in MeOH, was added PPTS (11 mg, 45 μmol), and the mixture was stirred for 16 hours. Solvent was then removed in vacuo to give a residue which was purified by Combiflash chromatography to give the product as an oil (30 mg, 61%). MS ESI m/e: 331.2 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08030354B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-9b4585d19f014e1692ba0a52fdd9ec29 |
| Source note | uspto-grants-2011_10 |