HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1662472Generated: October 29, 2026
Cesium carbonate → Methyl 2-((2,6-dimethyl-1-piperidinyl)methyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-4-carboxylate
https://huagongshe.com/reaction/1662472
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | Nanofin | HCID 68843 | — |
| Reactant | Methyl 2-(chloromethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-4-carboxylate | HCID 57706039 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | Methyl 2-((2,6-dimethyl-1-piperidinyl)methyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-4-carboxylate | HCID 57705951 | 30% |
Reaction Steps
A mixture of 66.69A (0.094 g, 0.30 mmol), 2,6-dimethylpiperidine (0.069 g, 0.61 mmol) (commercially available from Aldrich) and cesium carbonate (0.20 g, 0.61 mmol) in DMSO (4 mL) was stirred at 70° C. for 24 hours. The product was purified by reverse phase HPLC to give 66.69B in 30% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08030354B2 |
|---|
| Source dataset | uspto-grants-2011_10 |
|---|
| ORD ID | ord-32b1668f92044fdd9538ca2d25b3349b |
|---|
| Source note | uspto-grants-2011_10 |
|---|
