HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → (2R,5R)-1-((4-(Chloromethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-2-yl)methyl)-2,5-dimethylpyrrolidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | (2-(((2R,5R)-2,5-Dimethyl-1-pyrrolidinyl)methyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-4-yl)methanol | HCID 57706802 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (2R,5R)-1-((4-(Chloromethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-2-yl)methyl)-2,5-dimethylpyrrolidine | HCID 57705528 | 92.1% |
Reaction Steps
Thionyl chloride (0.25 g, 2.1 mmol) was added to a solution of 66.71B (0.029 g, 0.084 mmol) in DCM (0.7 mL) and the mixture was stirred at room temperature for 1 hour. After removing solvent, 66.71C (28 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08030354B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-8f59a5ea0b594214868b9f7be59ad421 |
| Source note | uspto-grants-2011_10 |