Methanol → HCID 57706237, compound

HRID 1662496Notes

Reaction equation

HRID 1662496 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH3:9])=[CH:4][C:3]=1[C:10]1[CH:15]=[CH:14][C:13]([C:16]([O:18][CH3:19])=[O:17])=[CH:12][C:11]=1[CH:20]1C[CH2:23][CH:22](I)[C:21]1([CH3:27])[CH3:26].C[OH:29]>[C].[Pd]>[CH3:26][C:21]1([CH3:27])[CH2:22][CH2:23][O:29][CH:20]1[C:11]1[CH:12]=[C:13]([C:16]([O:18][CH3:19])=[O:17])[CH:14]=[CH:15][C:10]=1[C:3]1[CH:4]=[C:5]([O:8][CH3:9])[CH:6]=[CH:7][C:2]=1[F:1]

Participants

4

Reactant 2

HCID 887MethanolHCID 67360786HCID 67360786, compound

Product 1

HCID 57706237HCID 57706237, compound

Reagents, catalysts & solvents 1

HCID 178418390HCID 178418390, compoundCatalyst

Procedure

To a solution of 66.60E (0.388 g, 0.801 mmol) in MeOH (17 mL) (degassed by N2), was added palladium-carbon (0.0853 g, 0.801 mmol). The resulting mixture was stirred at room temperature under H2 for 23 hours. After removing solvent, the residue was purified by flash chromatography (silica gel, 1:19 EtOAc/hexane) and gave 65 mg of 69.43A. MS ESI (pos.) m/e: 376 (M+18)+.

Workup

  1. customAfter removing solvent
  2. customthe residue was purified by flash chromatography (silica gel, 1:19 EtOAc/hexane)

Sources & evidence

ORD record
ord-b0515cb7827941ea86483f53bed5b995
Source dataset
uspto-grants-2011_10
Patent number
US08030354B2

Reaction notes

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