(3R)-3-(3-(((2-((1R)-2,2-Dimethylcyclopentyl)-3'-(methyloxy)-1,1'-biphenyl-4-yl)methyl)oxy)phenyl)pentanoic acid → Methyl 2-(2,2-dimethylcyclopentyl)-3'-(methyloxy)-1,1'-biphenyl-4-carboxylate

Participants

Reaction Steps

(3R)-3-(3-(((2-((1R)-2,2-Dimethylcyclopentyl)-3′-(methyloxy)-1,1′-biphenyl-4-yl)methyl)oxy)phenyl)pentanoic acid or (3R)-3-(3-(((2-((1S)-2,2-dimethylcyclopentyl)-3′-(methyloxy)-1,1′-biphenyl-4-yl)methyl)oxy)phenyl)pentanoic acid or (3S)-3-(3-(((2-((1R)-2,2-dimethylcyclopentyl)-3′-(methyloxy)-1,1′-biphenyl-4-yl)methyl)oxy)phenyl)pentanoic acid or (3S)-3-(3-(((2-((1S)-2,2-dimethylcyclopentyl)-3′-(methyloxy)-1,1′-biphenyl-4-yl)methyl)oxy)phenyl)pentanoic acid (78.5). The title compound was prepared from chloromethyl compound 78.5F or 78.5G derived from 78.5E (peak two from the separation of the racemic alcohol) using the methods described herein. MS ESI (pos.) m/e: 504.2 (M+H2O)+, 509.2 (M+Na)+.

Provenance & Evidence