2,2-Dimethyl-5-(1-methylethylidene)-1,3-dioxane-4,6-dione → 5-(2-(3-Methoxyphenyl)propan-2-yl)-2,2-dimethyl-1,3-dioxane-4,6-dione

Participants

Role	Name	HCID	Charge
Reactant	2,2-Dimethyl-5-(1-methylethylidene)-1,3-dioxane-4,6-dione	HCID 75218	—
Reactant	3-(3-(((2-Methyl-3'-(methyloxy)-1,1'-biphenyl-4-yl)methyl)oxy)phenyl)propanoic acid	HCID 25261298	—
Reactant	HCID 178490745	HCID 178490745	—
Product	5-(2-(3-Methoxyphenyl)propan-2-yl)-2,2-dimethyl-1,3-dioxane-4,6-dione	HCID 57707254	—

Reaction Steps

The 5-(2-(3-methoxyphenyl)propan-2-yl)-2,2-dimethyl-1,3-dioxane-4,6-dione (85.C) was prepared via the procedure described in Huang, X.; et. al.; Tetrahedron Letters; 1982, (1); pp. 75-76. from (3-methoxyphenyl)magnesium bromide (1.0 M in THF solution from Aldrich) and 85.B. 1H NMR (400 MHz, CDCl3) ppm 7.26 (1H, t, J=8.0 Hz), 6.94 (1H, d, J=7.8 Hz), 6.89 (1H, t, J=2.2 Hz), 6.79 (1H, dd, J=8.2, 2.3 Hz), 3.81 (3H, s), 3.62 (1H, s), 1.67 (6H, s), 1.66 (3H, s), 1.34 (3H, s).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08030354B2
Source dataset	uspto-grants-2011_10
ORD ID	ord-d48484c1f17542a7806160f29f287c19
Source note	uspto-grants-2011_10