Potassium Fluoride → Methyl 3-(2,5-difluoro-3-hydroxyphenyl)pentanoate

Participants

Reaction Steps

A screw-cap vial was charged with 90.F (0.23 g, 0.64 mmol), DMF (2.5 mL), and potassium fluoride (0.075 g, 1.3 mmol). The mixture was stirred for 5 minutes at room temperature, quenched with 1 N HCl, and diluted with EtOAc. The organics were washed with water and brine, dried (MgSO4), and concentrated. The crude product was purified by silica gel flash chromatography (0-20% EtOAc/hexane) to afford 90.G (0.13 g, 83% yield) as a colorless oil.

Provenance & Evidence