反应详情

A screw-cap vial was charged with 90.F (0.23 g, 0.64 mmol), DMF (2.5 mL), and potassium fluoride (0.075 g, 1.3 mmol). The mixture was stirred for 5 minutes at room temperature, quenched with 1 N HCl, and diluted with EtOAc. The organics were washed with water and brine, dried (MgSO4), and concentrated. The crude product was purified by silica gel flash chromatography (0-20% EtOAc/hexane) to afford 90.G (0.13 g, 83% yield) as a colorless oil.

1. customquenched with 1 N HCl
2. additiondiluted with EtOAc
3. washThe organics were washed with water and brine
4. dry with materialdried (MgSO4)
5. concentrationconcentrated
6. customThe crude product was purified by silica gel flash chromatography (0-20% EtOAc/hexane)