Trifluoroacetic acid → HCID 86625683, compound

HRID 1662592Notes

Reaction equation

HRID 1662592 reaction equation
[OH:1][C@H:2]1[CH2:6][N:5](C(OC(C)(C)C)=O)[C@H:4]([C:14]([O:16][CH3:17])=[O:15])[CH2:3]1.[C:18]([OH:24])([C:20]([F:23])([F:22])[F:21])=[O:19]>C(Cl)(Cl)Cl>[F:21][C:20]([F:23])([F:22])[C:18]([OH:24])=[O:19].[OH:1][C@H:2]1[CH2:6][NH:5][C@H:4]([C:14]([O:16][CH3:17])=[O:15])[CH2:3]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 2734883(2S,4R)-4-Hydroxypyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester

Product 1

HCID 86625683HCID 86625683, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

To a solution of 2.00 g of 1-tert-butyl 2-methyl (2S,4R)-4-hydroxypyrrolidine-1,2-dicarboxylate in CHCl3 (20 ml) was added TFA (10 ml) under ice cooling, the reaction mixture was warmed to room temperature, then was stirred for 3 hours at the same temperature. Thereafter, the reaction solution was concentrated under reduced pressure to obtain 3.82 g of the title compound (crude form, colorless oil). The present compound was used in the next reaction without purification.

Workup

  1. concentrationThereafter, the reaction solution was concentrated under reduced pressure

Sources & evidence

ORD record
ord-1a82d158bfc746d8a353e8950165b66c
Source dataset
uspto-grants-2011_10
Patent number
US08030499B2

Reaction notes

Loading…