3,5-Dichloro-3-(2-methoxyphenyl)indolin-2-one → Methyl(4s)-1-[5-chloro-3-(2-methoxyphenyl)-2-oxo-2,3-dihydro-1h-indol-3-yl]-4-fluoro-l-prolinate

反応式

ClC1(C2C=CC=CC=2OC)C2C(=CC=C(Cl)C=2)NC1=O.FC(F)(F)C(O)=O.F[C@@H]1CN[C@H](C(OC)=O)C1.[Cl:38][C:39]1[CH:40]=[C:41]2[C:45](=[CH:46][CH:47]=1)[N:44](S(C1C=CC(OC)=CC=1OC(F)(F)F)(=O)=O)[C:43](=[O:64])[C:42]2([N:73]1[CH2:81][C@@H:80]([F:82])[CH2:79][C@H:74]1[C:75]([O:77][CH3:78])=[O:76])[C:65]1[CH:70]=[CH:69][CH:68]=[CH:67][C:66]=1[O:71][CH3:72]>>[Cl:38][C:39]1[CH:40]=[C:41]2[C:45](=[CH:46][CH:47]=1)[NH:44][C:43](=[O:64])[C:42]2([N:73]1[CH2:81][C@@H:80]([F:82])[CH2:79][C@H:74]1[C:75]([O:77][CH3:78])=[O:76])[C:65]1[CH:70]=[CH:69][CH:68]=[CH:67][C:66]=1[O:71][CH3:72]

参加物

反応物 3

HCID 219059133,5-Dichloro-3-(2-methoxyphenyl)indolin-2-one

HCID 59867772HCID 59867772、化合物

HCID 67429745HCID 67429745、化合物

生成物 1

HCID 67428197Methyl(4s)-1-[5-chloro-3-(2-methoxyphenyl)-2-oxo-2,3-dihydro-1h-indol-3-yl]-4-fluoro-l-prolinate

実験手順

With 1.70 g of 3,5-dichloro-3-(2-methoxyphenyl)-1,3-dihydro-2H-indol-2-one and 1.03 g of the compound obtained in Step 16-1 as starting materials, 1.98 g of a diastereoisomer mixture of the title compound (pea green amorphous) was obtained by a similar method to Step 4-2.

出典と根拠

ORDレコード: ord-7c205816ea774a3383230ddef44c7d4e
出典データセット: uspto-grants-2011_10
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08030499B2

反応ノート

読み込み中…