3,5-Dichloro-3-(2-methoxyphenyl)indolin-2-one → Methyl(4s)-1-[5-chloro-3-(2-methoxyphenyl)-2-oxo-2,3-dihydro-1h-indol-3-yl]-4-fluoro-l-prolinate

Participants

Reaction Steps

With 1.70 g of 3,5-dichloro-3-(2-methoxyphenyl)-1,3-dihydro-2H-indol-2-one and 1.03 g of the compound obtained in Step 16-1 as starting materials, 1.98 g of a diastereoisomer mixture of the title compound (pea green amorphous) was obtained by a similar method to Step 4-2.

Provenance & Evidence