HRID1662611

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COc1ccccc1C1(N2C[C@H](F)C[C@H]2C(=O)N(C)C)C(=O)Nc2ccc(OC(F)(F)F)cc21

HCID67429458

未命名化合物

HCID86625684

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(S(=O)(=O)N2C(=O)C(c3ccccc3OC)(N3C[C@H](F)C[C@H]3C(=O)N(C)C)c3cc(OC(F)(F)F)ccc32)c(OC(F)(F)F)c1

HCID59867834

未命名化合物

收率 51.7%

PROCEDURE

实验过程

With 200 mg of the compound obtained in Step 20-1 (Isomer B) and 133 mg of 4-methoxy-2-(trifluoromethoxy)benzene sulfonyl chloride as starting material, 158 mg of the title compound (colorless amorphous) was obtained by a similar method to Example 2.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-e744cb03e36142e29246d5d43a16cd15
来源数据集: uspto-grants-2011_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08030499B2
来源说明: uspto-grants-2011_10

反应 SMILES

[F:1][C@H:2]1[CH2:6][N:5]([C:7]2([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=3[O:28][CH3:29])[C:15]3[C:10](=[CH:11][CH:12]=[C:13]([O:16][C:17]([F:20])([F:19])[F:18])[CH:14]=3)[NH:9][C:8]2=[O:21])[C@H:4]([C:30]([N:32]([CH3:34])[CH3:33])=[O:31])[CH2:3]1.[CH3:35][O:36][C:37]1[CH:42]=[CH:41][C:40]([S:43](Cl)(=[O:45])=[O:44])=[C:39]([O:47][C:48]([F:51])([F:50])[F:49])[CH:38]=1>>[F:1][C@H:2]1[CH2:6][N:5]([C:7]2([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=3[O:28][CH3:29])[C:15]3[C:10](=[CH:11][CH:12]=[C:13]([O:16][C:17]([F:20])([F:19])[F:18])[CH:14]=3)[N:9]([S:43]([C:40]3[CH:41]=[CH:42][C:37]([O:36][CH3:35])=[CH:38][C:39]=3[O:47][C:48]([F:49])([F:50])[F:51])(=[O:45])=[O:44])[C:8]2=[O:21])[C@H:4]([C:30]([N:32]([CH3:33])[CH3:34])=[O:31])[CH2:3]1