(4R)-4-fluoro-1-[3-(2-methoxyphenyl)-2-oxo-5-(trifluoromethoxy)-2,3-dihydro-1H-indol-3-yl]-N,N-dimethyl-L-prolinamide → (4R)-4-fluoro-1-[3-(2-methoxyphenyl)-1-{[4-methoxy-2-(trifluoromethoxy)phenyl]sulfonyl}-2-o xo-5-(trifluoromethoxy)-2,3-dihydro-1H-indol-3-yl]-N,N-dimethyl-L-prolinamide

Participants

Reaction Steps

With 200 mg of the compound obtained in Step 20-1 (Isomer B) and 133 mg of 4-methoxy-2-(trifluoromethoxy)benzene sulfonyl chloride as starting material, 158 mg of the title compound (colorless amorphous) was obtained by a similar method to Example 2.

Provenance & Evidence