HRID1662619

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CN(C)C(=O)[C@@H]1C[C@@H](F)CN1C1(Cc2ccccc2)C(=O)Nc2ccc(Cl)cc21

HCID67429949

未命名化合物

HCID86625684

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(S(=O)(=O)N2C(=O)C(Cc3ccccc3)(N3C[C@H](F)C[C@H]3C(=O)N(C)C)c3cc(Cl)ccc32)c(OC(F)(F)F)c1

HCID11951805

未命名化合物

收率 47.8%

PROCEDURE

实验过程

With 87 mg of the compound obtained in Step 30-2 and of 74 mg 4-methoxy-2-(trifluoromethoxy)benzene sulfonyl chloride as starting materials, 67 mg of the title compound (colorless solid) was obtained by a similar method to Example 2.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-0e880950c86141e78cb63f4c5ca9d04a
来源数据集: uspto-grants-2011_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08030499B2
来源说明: uspto-grants-2011_10

反应 SMILES

[CH2:1]([C:8]1([N:19]2[CH2:28][C@H:27]([F:29])[CH2:26][C@H:20]2[C:21]([N:23]([CH3:25])[CH3:24])=[O:22])[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([Cl:17])[CH:15]=2)[NH:10][C:9]1=[O:18])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:30][O:31][C:32]1[CH:37]=[CH:36][C:35]([S:38](Cl)(=[O:40])=[O:39])=[C:34]([O:42][C:43]([F:46])([F:45])[F:44])[CH:33]=1>>[CH2:1]([C:8]1([N:19]2[CH2:28][C@H:27]([F:29])[CH2:26][C@H:20]2[C:21]([N:23]([CH3:25])[CH3:24])=[O:22])[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([Cl:17])[CH:15]=2)[N:10]([S:38]([C:35]2[CH:36]=[CH:37][C:32]([O:31][CH3:30])=[CH:33][C:34]=2[O:42][C:43]([F:44])([F:45])[F:46])(=[O:40])=[O:39])[C:9]1=[O:18])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1