5-chloro-3-(2-methoxyphenyl)-3-[2-oxo-2-(4-pyridin-2-ylpiperazin-1-yl)ethyl]-1,3-dihydro-2H-indol-2-one → 5-chloro-3-(2-methoxyphenyl)-1-{[4-methoxy-2-(trifluoromethoxy)phenyl]sulfonyl}-3-[2-oxo-2-(4-pyridin-2-ylpiperazin-1-yl)ethyl]-1,3-dihydro-2H-indol-2-one

Participants

Reaction Steps

With 300 mg of the compound obtained in Step 47-1 and 201 mg of 4-methoxy-2-(trifluoromethoxy)benzene sulfonyl chloride as starting materials, 410 mg of free form of the title compound (pale yellow amorphous) was obtained by a similar method to Example 2. In a similar procedure to Example 43, 383 mg of the obtained free form underwent salt formation and was solidified to obtain 405 mg of the title compound (pale yellow solid).

Provenance & Evidence