1-(4-Pyridyl)piperazine → HCID 11950550, compound

HRID 1662646Notes

Reaction equation

HRID 1662646 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([S:11]([C:14]1[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][C:15]=1[O:22][C:23]([F:26])([F:25])[F:24])(=[O:13])=[O:12])[C:6](=[O:27])[C:5]2([NH:36][CH2:37][C:38](O)=[O:39])[C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=1[O:34][CH3:35].[N:41]1[CH:46]=[CH:45][C:44]([N:47]2[CH2:52][CH2:51][NH:50][CH2:49][CH2:48]2)=[CH:43][CH:42]=1>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([S:11]([C:14]1[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][C:15]=1[O:22][C:23]([F:25])([F:26])[F:24])(=[O:13])=[O:12])[C:6](=[O:27])[C:5]2([C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=1[O:34][CH3:35])[NH:36][CH2:37][C:38](=[O:39])[N:50]1[CH2:51][CH2:52][N:47]([C:44]2[CH:45]=[CH:46][N:41]=[CH:42][CH:43]=2)[CH2:48][CH2:49]1

Participants

3

Reactant 2

HCID 705171-(4-Pyridyl)piperazineHCID 67428061HCID 67428061, compound

Product 1

HCID 11950550HCID 11950550, compoundYield 75.2%

Procedure

With 300 mg of the compound obtained in Step 58-2 and 89 mg of 1-pyridin-4-yl piperazine as starting material, 280 mg of the title compound (colorless amorphous) was obtained by a similar method to Step 51-2.

Sources & evidence

ORD record
ord-af46ebc3f1d84fe7bc26da2ef9da163e
Source dataset
uspto-grants-2011_10
Patent number
US08030499B2

Reaction notes

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