HCID 21925466, compound → HCID 67428844, compound

HRID 1662647Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[C:5]2([NH:20][CH2:21][CH2:22][C:23]([O:25][C:26]([CH3:29])([CH3:28])[CH3:27])=[O:24])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[O:18][CH3:19].[CH3:30][O:31][C:32]1[CH:37]=[CH:36][C:35]([S:38](Cl)(=[O:40])=[O:39])=[C:34]([O:42][C:43]([F:46])([F:45])[F:44])[CH:33]=1>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([S:38]([C:35]1[CH:36]=[CH:37][C:32]([O:31][CH3:30])=[CH:33][C:34]=1[O:42][C:43]([F:44])([F:45])[F:46])(=[O:40])=[O:39])[C:6](=[O:11])[C:5]2([NH:20][CH2:21][CH2:22][C:23]([O:25][C:26]([CH3:29])([CH3:28])[CH3:27])=[O:24])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[O:18][CH3:19]

Participants

Reactant 2

HCID 21925466HCID 21925466, compound

HCID 866256844-Methoxy-2-(trifluoromethoxy)benzene sulfonyl chloride

Product 1

HCID 67428844HCID 67428844, compoundYield 88.2%

Procedure

With 1.50 g of tert-butyl N-[5-chloro-3-(2-methoxyphenyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-β-alaninate, which is the compound described in Preparation 1.29A of the brochure Publication No. WO03/008407, and 1.15 g of 4-methoxy-2-(trifluoromethoxy)benzene sulfonyl chloride as starting materials, 2.13 g of the title compound (light yellow solid) was obtained by a similar method to Example 2.

Sources & evidence

ORD record: ord-100ee27e584d45afbacd8e7d46dbfdf6
Source dataset: uspto-grants-2011_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08030499B2

Reaction notes

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