HCID 67427843, compound → HCID 59867901, compound

HRID 1662653Notes

Reaction equation

HRID 1662653 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[C:5]2([NH:20][C@@H:21]([CH2:27][OH:28])[C:22]([N:24]([CH3:26])[CH3:25])=[O:23])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[O:18][CH3:19].[CH3:29][O:30][C:31]1[CH:36]=[CH:35][C:34]([S:37](Cl)(=[O:39])=[O:38])=[C:33]([O:41][C:42]([F:45])([F:44])[F:43])[CH:32]=1>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([S:37]([C:34]1[CH:35]=[CH:36][C:31]([O:30][CH3:29])=[CH:32][C:33]=1[O:41][C:42]([F:43])([F:44])[F:45])(=[O:39])=[O:38])[C:6](=[O:11])[C:5]2([NH:20][C@@H:21]([CH2:27][OH:28])[C:22]([N:24]([CH3:25])[CH3:26])=[O:23])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[O:18][CH3:19]

Participants

3

Reactant 2

HCID 67427843HCID 67427843, compoundHCID 866256844-Methoxy-2-(trifluoromethoxy)benzene sulfonyl chloride

Product 1

HCID 59867901HCID 59867901, compound

Procedure

With 0.88 g of the compound obtained in Step 65-3 and 0.649 g of 4-methoxy-2-(trifluoromethoxy)benzene sulfonyl chloride as starting materials, respectively 140 mg (Isomer A, colorless amorphous) and 170 mg (Isomer B, colorless amorphous) of two species of diastereoisomers of the title compound were obtained by a similar method to Example 2.

Sources & evidence

ORD record
ord-8742d8f3ec5c44fd94c8ec3dc2d21227
Source dataset
uspto-grants-2011_10
Patent number
US08030499B2

Reaction notes

Loading…