Trifluoroacetic acid → HCID 67429183, compound

HRID 1662680Notes

Reaction equation

HRID 1662680 reaction equation
C(OC(=O)[NH:7][C@@H:8]([CH2:14][C:15]1[CH:20]=[CH:19][C:18]([O:21][CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)=[CH:17][CH:16]=1)[C:9]([N:11]([CH3:13])[CH3:12])=[O:10])(C)(C)C.[C:30]([OH:36])([C:32]([F:35])([F:34])[F:33])=[O:31]>C(Cl)(Cl)Cl>[F:33][C:32]([F:35])([F:34])[C:30]([OH:36])=[O:31].[NH2:7][C@@H:8]([CH2:14][C:15]1[CH:20]=[CH:19][C:18]([O:21][CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)=[CH:17][CH:16]=1)[C:9]([N:11]([CH3:13])[CH3:12])=[O:10]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 131729222HCID 131729222, compound

Product 1

HCID 67429183HCID 67429183, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

To a solution of 2.00 g of the compound obtained in Step 86-2 in CHCl3 (30 ml) was added TFA (6 ml) under ice cooling, then, the reaction solution was stirred at room temperature for 13 hours. The reaction solution was concentrated under reduced pressure to obtain 3.47 g of the title compound (yellow oil form, crude form).

Workup

  1. concentrationThe reaction solution was concentrated under reduced pressure

Sources & evidence

ORD record
ord-4ca7e961eefe4bf6b4c104688d6d5401
Source dataset
uspto-grants-2011_10
Patent number
US08030499B2

Reaction notes

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