Tetrahydrofuran → HCID 11263835, compound

HRID 1662682Notes

Reaction equation

HRID 1662682 reaction equation
C(OC(=O)[NH:10][C@@H:11]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[C:12]([N:14]([CH3:16])[CH3:15])=[O:13])C1C=CC=CC=1.C1COCC1>CCO.[C].[Pd]>[NH2:10][C@@H:11]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[C:12]([N:14]([CH3:16])[CH3:15])=[O:13]

Participants

5

Reactant 2

HCID 8028TetrahydrofuranHCID 58605025HCID 58605025, compound

Product 1

HCID 11263835HCID 11263835, compoundYield 101.8%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

A suspension of 1.67 g of the compound obtained in Step 87-1 and 0.17 g of 10% palladium-carbon in EtOH (20 ml) was stirred at room temperature for 14 hours under hydrogen atmosphere. The stirred solution was added with THF (1 ml) and stirred at room temperature for 1 hour under hydrogen atmosphere. The insoluble matter was separated by filtration and the filtrate was concentrated under reduced pressure to obtain 0.97 g of the title compound (pale yellow solid, crude form).

Workup

  1. stirringstirred at room temperature for 1 hour under hydrogen atmosphere
  2. customThe insoluble matter was separated by filtration
  3. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-794615e45bdc4c779f03a1a56db9daf2
Source dataset
uspto-grants-2011_10
Patent number
US08030499B2

Reaction notes

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