2-Bromo-4-methylanisole → 5-bromo-3-hydroxy-3-(2-methoxy-5-methylphenyl)-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one

HRID 1662705Notes

Reaction equation

HRID 1662705 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:10](=[O:11])[C:9](=[O:12])[NH:8][C:5]2=[N:6][CH:7]=1.Br[C:14]1[CH:15]=[C:16]([CH3:22])[CH:17]=[CH:18][C:19]=1[O:20][CH3:21]>>[Br:1][C:2]1[CH:3]=[C:4]2[C:10]([OH:11])([C:14]3[CH:15]=[C:16]([CH3:22])[CH:17]=[CH:18][C:19]=3[O:20][CH3:21])[C:9](=[O:12])[NH:8][C:5]2=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 891432-Bromo-4-methylanisoleHCID 533020255-Bromo-1H-pyrrolo[2,3-b]pyridine-2,3-dione

Product 1

HCID 674285555-bromo-3-hydroxy-3-(2-methoxy-5-methylphenyl)-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-oneYield 58.5%

Procedure

With 2.00 g of the compound obtained in Step 120-3 and 2.26 g of 3-bromo-4-methoxy toluene as starting materials, 1.80 g of the title compound was obtained by a similar method to Step 21-1.

Sources & evidence

ORD record
ord-f48aec5d3b9949e8af9c51ac86ef86db
Source dataset
uspto-grants-2011_10
Patent number
US08030499B2

Reaction notes

Loading…